Original bundle-based management of septic shock in nagoya university emergency icu

Methods This study adopted retrospective analysis. As the basis for management of septic shock, 13 main elements were combined as the management bundle of septic shock, which contained antibiotics followed culture sampling, standard precaution, infusion therapy adjusted with echocardiogram, early goal-directed original infusion methods, lactate clearance, open lung strategy, analgesia and sedation, b-adrenergic receptor non-stimulation, urine volume management, continuous henofiltration, early enteral nutrition within 48 hours, and early rehabilitation within three days. We analyzed the feasibility and the outcome for septic shock in accordance with this policy from 1st May 2011 to 31st December 2014 as compared with in-ICU mortality rate of more than 25% in 2010.